Description

5,8-Difluoro-7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One is a high-purity fluorinated naphthalenone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular scaffold, which is engineered for the development of novel active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex, fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, leveraging the fluorine atoms to improve lipophilicity and target binding.
• Material Science Precursor: Serves as a monomer or precursor for creating specialty polymers and organic electronic materials with tailored optical or electronic properties.
• Chemical Synthesis Reagent: Employed in academic and industrial R&D for constructing complex polycyclic structures via reactions like cross-coupling, cyclization, or functional group transformations.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of specific fluorine substitution patterns on chemical reactivity and physical properties.

Basic Information

Product Name	5,8-Difluoro-7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One
CAS No.	1092347-75-5
Molecular Formula	C₁₁H₁₀F₂O₂
Molecular Weight	212.19 g/mol
Synonyms	5,8-Difluoro-7-methoxy-3,4-dihydro-1(2H)-naphthalenone; 5,8-Difluoro-7-methoxy-1-tetralone; 1(2H)-Naphthalenone, 5,8-difluoro-7-methoxy-3,4-dihydro-; 5,8-Difluoro-7-methoxy-3,4-dihydro-1H-naphthalen-1-one; 5,8-Difluoro-7-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene; 7-Methoxy-5,8-difluoro-3,4-dihydronaphthalen-1(2H)-one
EINECS	Contact for details

Quality Control

Our production of 5,8-Difluoro-7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and released against comprehensive specifications, including identity confirmation by spectroscopic methods and purity assessment by advanced chromatographic techniques. Certificates of Analysis (COA) detailing all critical quality attributes are provided with each shipment. Our quality system is designed to support cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.