Description

2-(4-Bromophenyl)-4,4,6-Trimethyl-1,3,2-Dioxaborinane is a high-purity organoboron reagent, specifically a cyclic boronic ester, valued for its stability and reactivity in advanced synthetic chemistry. This compound is a critical building block for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient formation of carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality intermediates for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific biphenyl or aryl structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for studying biological processes and target identification.
• Academic & Industrial R&D: A fundamental reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	2-(4-Bromophenyl)-4,4,6-Trimethyl-1,3,2-Dioxaborinane
CAS No.	1092060-78-0
Molecular Formula	C13H18BBrO2
Molecular Weight	297.00 g/mol
Synonyms	4-Bromophenylboronic acid, 4,4,6-trimethyl-1,3,2-dioxaborinane ester; (4-Bromophenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane; 2-(4-Bromophenyl)-4,4,6-trimethyl-2H-1,3,2-dioxaborinane; 4,4,6-Trimethyl-2-(4-bromophenyl)-1,3,2-dioxaborinane; 4-Bromophenylboronic acid cyclic ester with 2,2,4-trimethyl-1,3-pentanediol; 4-Bromophenyl MIDA boronate (related protected form); 4-Bromo-benzeneboronic acid 2,2,4-trimethyl-1,3-pentanediol ester
EINECS	Contact for details

Quality Control

Our 2-(4-Bromophenyl)-4,4,6-Trimethyl-1,3,2-Dioxaborinane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) and opened only in a moisture-controlled environment, such as a glovebox, to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.