Description

2-(Difluoromethoxy)Acetic Acid is a specialized fluorinated organic acid building block of significant interest in advanced chemical synthesis. Its unique difluoromethoxy-acetic acid structure makes it a valuable precursor for introducing fluorinated motifs, which are critical for modulating the physicochemical properties of target molecules. This compound is primarily utilized by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated ether or acid functionalities to enhance metabolic stability, bioavailability, or membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or modifier in the development of specialty polymers and coatings with tailored surface properties, chemical resistance, or durability.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel chelating agents or catalysts for asymmetric synthesis and other specialized reactions.
• Fluorine Chemistry Research: An essential reagent for academic and industrial laboratories exploring new methodologies for incorporating fluorine atoms into complex organic frameworks.

Basic Information

Product Name	2-(Difluoromethoxy)Acetic Acid
CAS No.	1089695-61-3
Molecular Formula	C3H4F2O3
Molecular Weight	126.06 g/mol
Synonyms	Acetic acid, 2-(difluoromethoxy)-; Difluoromethoxyacetic acid; 2-(Difluoromethoxy)ethanoic acid; α-(Difluoromethoxy)acetic acid; (Difluoromethoxy)acetic acid
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Acetic Acid is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency for your critical synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its nature as a strong acid/organic solvent, it should be kept away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.