Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Piperidine CAS NO 1087160-40-4 is a high-value, protected boronic ester derivative of piperidine, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the piperidine moiety into active pharmaceutical ingredients (APIs) and drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the piperidine-boronate functionality allows for the creation of diverse chemical libraries for biological screening.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysis, and novel polymers where precise molecular architecture is required.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-couplings with organic halides to form biaryl and other conjugated systems efficiently.
• Medicinal Chemistry: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies due to its stability and reactivity under standard coupling conditions.
• Chemical Biology: Acts as a versatile handle for bioconjugation and the synthesis of chemical probes for target identification and validation.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Piperidine
CAS No.	1087160-40-4
Molecular Formula	C11H22BNO2
Molecular Weight	211.11 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine; Piperidine-4-boronic acid pinacol ester; 4-(Pinacolatoboryl)piperidine; 4-Piperidineboronic acid pinacol ester; 4-Boronopiperidine pinacol ester; 4-Piperidinylboronic acid pinacol ester; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine; 1087160-40-4
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. All products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as boronic esters can be sensitive to prolonged exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.