Description

2-(Chloromethyl)-5-(Methylsulfonyl)-Benzotrifluoride is a high-value, multi-functional chemical intermediate characterized by its reactive chloromethyl and electron-withdrawing methylsulfonyl and trifluoromethyl groups. This compound matters for its role as a key building block in the synthesis of complex molecules, enabling the introduction of specific functional groups critical for advanced material properties and biological activity. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and performance materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring sulfonyl and trifluoromethyl motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the benzotrifluoride core enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and electronic materials where its specific substituents can tune electronic and physical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-directed research and scale-up projects requiring this specific molecular architecture.

Basic Information

Product Name	2-(Chloromethyl)-5-(Methylsulfonyl)-Benzotrifluoride
CAS No.	1086389-83-4
Molecular Formula	C9H8ClF3O2S
Molecular Weight	272.67 g/mol
Synonyms	5-(Methylsulfonyl)-2-(chloromethyl)benzotrifluoride; 2-Chloromethyl-5-methylsulfonylbenzotrifluoride; 1-Chloromethyl-4-(methylsulfonyl)-2-(trifluoromethyl)benzene; α,α,α-Trifluoro-5-(methylsulfonyl)-o-tolyl Chloride; Benzene, 1-(chloromethyl)-4-(methylsulfonyl)-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-5-(Methylsulfonyl)-Benzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging, or stored in darkness. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.