Description

3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-amine is a high-value, protected boronic ester derivative of an aminopyrazine, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes it an ideal, stable reagent for palladium-catalyzed cross-coupling with aryl or vinyl halides to form biaryl or styryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate functionalized pyrazine cores.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands or metal-organic frameworks (MOFs) used in catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers, where the pyrazine unit can influence electronic properties.
• Chemical Biology & Proteomics: Can be utilized to create molecular probes or tags for studying biological systems and protein interactions.

Basic Information

Product Name	3-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Amine
CAS No.	1084953-50-3
Molecular Formula	C11H18BN3O3
Molecular Weight	251.10 g/mol
Synonyms	2-Amino-3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methoxypyrazin-2-amine; 3-Methoxypyrazin-2-amine-5-boronic acid pinacol ester; 2-Pyrazinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methoxy-; Aminopyrazine boronic ester; Pinacol boronate pyrazine derivative
EINECS	Contact for details

Quality Control

Our 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.