Description

3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-5-Trifluoromethyl-Pyridine is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing trifluoromethylpyridine motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require the introduction of the pyridine-boronate moiety.
• Material Science: Serves as a precursor for creating functional organic materials, liquid crystals, and metal-organic frameworks (MOFs) via cross-coupling polymerization.
• Chemical Biology & Diagnostics: Employed in the development of molecular probes, biomarkers, and labeling reagents due to its bio-orthogonal reactivity.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.
• Academic & Contract Research: A vital reagent for methodological development and discovery chemistry in university and CRO laboratories worldwide.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-5-Trifluoromethyl-Pyridine
CAS No.	1084953-47-8
Molecular Formula	C12H15BF3NO2
Molecular Weight	273.06 g/mol
Synonyms	5-(Trifluoromethyl)pyridine-3-boronic acid pinacol ester; 3-Pyridineboronic acid, 5-(trifluoromethyl)-, 1,1-dimethylethyl ester; 5-Trifluoromethyl-3-pyridylboronic acid pinacol ester; (5-(Trifluoromethyl)pyridin-3-yl)boronic acid pinacol ester; 3-Borono-5-trifluoromethylpyridine pinacol ester; 1084953-47-8; PINACOL 5-(TRIFLUOROMETHYL)PYRIDIN-3-YLBORONATE
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-5-Trifluoromethyl-Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.