Description

n-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Cyclopropanesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, which is crucial for modern cross-coupling reactions. This compound is specifically designed for the efficient synthesis of complex molecules, offering a critical building block for medicinal chemistry and drug discovery programs. It is primarily sought after by research institutions and pharmaceutical companies developing novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) diseases.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key pyridine-containing boronic ester reagent for constructing biaryl and heterobiaryl structures in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of small molecule drugs, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry & Drug Discovery: A versatile building block for creating compound libraries and optimizing lead structures in preclinical studies.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the development of novel herbicides or pesticides with specific activity.
• Material Science: Can be investigated as a monomer or precursor for functional organic materials and polymers.

Basic Information

Product Name	n-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Cyclopropanesulfonamide
CAS No.	1083327-53-0
Molecular Formula	C15H23BN2O4S
Molecular Weight	338.23 g/mol
Synonyms	Cyclopropanesulfonamide, N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-; 3-(Cyclopropylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(N-Cyclopropylsulfamoyl)pyridin-3-ylboronic acid pinacol ester; 1083327-53-0; 3-Cyclopropylsulfamoyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)cyclopropanesulfonamide.
EINECS	Contact for details

Quality Control

Our n-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Cyclopropanesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.