Description

2,4-Difluoro-n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Benzenesulfonamide is a high-value, multi-functional chemical intermediate featuring a pyridine core, a sulfonamide group, and a pinacol boronate ester. This compound matters because its unique structure makes it a critical building block for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions. Pharmaceutical R&D and fine chemical synthesis professionals need it for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and sulfonamide-based therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the difluorobenzene and pyridine motifs are active.
• Material Science Research: Serves as a monomer or functionalizing agent for creating specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The pinacol boronate ester group is specifically designed for efficient palladium-catalyzed Suzuki-Miyaura couplings with aryl/heteroaryl halides.
• Chemical Biology & Proteomics: Can be utilized as a molecular probe or linker in bioconjugation and target identification studies.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	2,4-Difluoro-n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Benzenesulfonamide
CAS No.	1083326-73-1
Molecular Formula	C19H23BF2N2O5S
Molecular Weight	440.27 g/mol
Synonyms	2,4-Difluoro-N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamide; 3-[(2,4-Difluorophenyl)sulfonylamino]-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1083326-73-1; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,4-difluorophenylsulfonyl)pyridin-3-amine; Boronic acid, B-[3-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Benzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis of the boronate ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.