Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for forming carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and reliable intermediates for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing pyrazine and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific pyrazine-based structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and development of new drug candidates through combinatorial chemistry and library synthesis.
• Cross-Coupling Reactions: Specifically designed as a stable, air-handleable reagent for palladium-catalyzed Suzuki-Miyaura couplings with various aryl/heteroaryl halides.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Item	Detail
Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine
CAS No.	1083179-99-0
Molecular Formula	C10H15BN2O2
Molecular Weight	206.05 g/mol
Synonyms	Pyrazine-2-boronic acid pinacol ester; 2-Pyrazinylboronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 2-Pyrazineboronic Acid Pinacol Ester; 2-(Pyrazin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Pyrazinyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening a new container to prevent hydrolysis and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.