Description

5-Chloro-2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, enabling the introduction of the pyridine moiety.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including ligands for OLEDs and other functional polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl/heteroaryl halides, facilitating carbon-carbon bond formation.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugates for target identification and binding studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	5-Chloro-2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1083168-96-0
Molecular Formula	C12H17BClNO3
Molecular Weight	269.53 g/mol
Synonyms	5-Chloro-2-methoxypyridine-3-boronic acid pinacol ester; 3-Borono-5-chloro-2-methoxypyridine pinacol ester; (5-Chloro-2-methoxypyridin-3-yl)boronic acid pinacol ester; 5-Chloro-2-methoxy-3-pyridineboronic acid pinacol ester; 1083168-96-0; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-chloro-2-methoxypyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and cGMP manufacturing. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (argon or nitrogen) in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.