Description

(2S)-2-[(tert-Butoxy)Carbonylamino]-2-(2-Naphthyl)Acetic Acid is a high-purity chiral amino acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined naphthylglycine scaffold, essential for constructing complex molecules with precise spatial orientation. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of protease inhibitors, receptor antagonists, and other therapeutic agents targeting central nervous system (CNS) and oncology pathways.
• Peptidomimetics & Constrained Peptide Design: Incorporation into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity by introducing rigid, aromatic side chains.
• Asymmetric Catalysis & Ligand Synthesis: Used to construct chiral ligands and organocatalysts for enantioselective transformations in process chemistry.
• Agrochemical Research: Building block for developing novel herbicides and fungicides with specific chiral activity.
• Material Science: Potential monomer for synthesizing specialty polymers with unique optical or electronic properties.
• Academic & Contract Research: Serves as a valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(2S)-2-[(tert-Butoxy)Carbonylamino]-2-(2-Naphthyl)Acetic Acid
CAS No.	1082750-59-1
Molecular Formula	C₁₇H₁₉NO₄
Molecular Weight	301.34 g/mol
Synonyms	Boc-2-Naphthylglycine; (S)-2-((tert-Butoxycarbonyl)amino)-2-(naphthalen-2-yl)acetic acid; N-Boc-2-naphthylglycine; (S)-N-Boc-2-(2-Naphthyl)glycine; (2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-(2-naphthalenyl)acetic acid; Boc-L-2-Naphthylglycine; N-(tert-Butoxycarbonyl)-2-naphthyl-L-glycine; (S)-2-(2-Naphthyl)-2-[(tert-butoxycarbonyl)amino]acetic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-[(tert-Butoxy)Carbonylamino]-2-(2-Naphthyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), chiral excess (typically ≥99% ee), and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.