Description

1H-Indazole, 1-(Tetrahydro-2H-Pyran-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative of indazole, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity components for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting kinases and other enzyme families.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl halides, enabling efficient carbon-carbon bond formation.
• Drug Discovery & Medicinal Chemistry: Used extensively in high-throughput screening and combinatorial chemistry to create diverse libraries of indazole-based compounds for biological evaluation.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that utilize the indazole scaffold.
• Material Science & Organic Electronics: Serves as a monomer or building block for creating organic semiconductors, ligands for catalysts, and advanced polymers.
• Chemical Biology & Probe Development: Utilized to create molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	1H-Indazole, 1-(Tetrahydro-2H-Pyran-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1082525-64-1
Molecular Formula	C18H25BN2O3
Molecular Weight	328.22 g/mol
Synonyms	1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1H-Indazole-5-boronic acid, 1-(tetrahydro-2H-pyran-2-yl)-, pinacol ester; 1-THP-5-Bpin-indazole; 5-BPin-1-THP-indazole; 1-(THP)-Indazole-5-Bpin
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 1-(Tetrahydro-2H-Pyran-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports compliance with the stringent requirements of pharmaceutical R&D and cGMP environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.