Description

1-(tert-Butyldimethylsilyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, protected heterocyclic boronic ester building block designed for advanced synthetic chemistry. This compound matters as a critical intermediate for constructing complex molecular architectures via cross-coupling reactions, enabling the development of novel active pharmaceutical ingredients (APIs) and functional materials. Pharmaceutical R&D and fine chemical synthesis laboratories need this reagent for its precise reactivity and role in streamlining the synthesis of challenging pyrrolopyridine-based targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics targeting oncology and CNS diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronate ester coupling partner for the introduction of the 1H-pyrrolo[2,3-b]pyridine scaffold into complex molecules.
• Agrochemical Research: Used in the discovery and development of new active ingredients with specific biological activity.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, electron-transport materials, and light-emitting compounds for electronic devices.
• Chemical Biology & Probe Development: Utilized to create tagged molecules and bioconjugates for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs producing complex, high-value compounds for clients.

Basic Information

Product Name	1-(tert-Butyldimethylsilyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1082525-61-8
Molecular Formula	C19H31BN2O2Si
Molecular Weight	358.36 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-[(1,1-dimethylethyl)dimethylsilyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-TBDMS-5-Bpin-7-azaindole; 1-(tert-Butyldimethylsilyl)-5-(pinacolboron)-7-azaindole; 5-Bpin-1-TBDMS-1H-pyrrolo[2,3-b]pyridine; N-TBDMS-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 1-(tert-Butyldimethylsilyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole
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Quality Control

Our 1-(tert-Butyldimethylsilyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including NMR (1H, 13C, 11B), HPLC, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent decomposition. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.