Description

1-(3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropan-2-Ol is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex carbon-carbon bonds. It is an essential building block for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality precursors for synthesizing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that utilize boronic acid chemistry.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and tools for studying biological processes and protein interactions.
• Catalyst & Ligand Development: Acts as a starting material for creating novel ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Academic & Industrial R&D: A versatile reagent for method development and exploratory synthesis in both university laboratories and corporate R&D centers.

Basic Information

Product Name	1-(3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropan-2-Ol
CAS No.	1082503-78-3
Molecular Formula	C15H27BN2O3
Molecular Weight	294.20 g/mol
Synonyms	2-Methyl-1-[3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]propan-2-ol; 2-Methyl-2-[3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol; 1-(3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; tert-Butyl 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate analog; Pinacol ester of 3,5-dimethyl-1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-boronic acid
EINECS	Contact for details

Quality Control

Our 1-(3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropan-2-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR (1H and 13C), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.