Description

(2,2,2-Trifluoroethyl)Hydrazinehydrochloride is a specialized organofluorine building block of significant interest in advanced synthetic chemistry. Its core value lies in the unique reactivity of the hydrazine moiety combined with the electron-withdrawing trifluoroethyl group, enabling the construction of complex heterocycles and fluorinated pharmacophores. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated pyrazoles, triazoles, and other nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoroethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Building block for creating fluorinated polymers, ligands, or metal-organic frameworks (MOFs) with tailored properties.
• Cross-coupling Reactions: Serves as a hydrazine source in palladium-catalyzed reactions for C-N bond formation.
• Fluorine Chemistry: Fundamental reagent for studying the introduction and effects of the -CH2CF3 group in molecular design.
• Custom Synthesis & Contract Manufacturing: Critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing targeted compounds for client R&D pipelines.

Basic Information

Item	Details
Product Name	(2,2,2-Trifluoroethyl)Hydrazinehydrochloride
CAS No.	1081515-82-3
Molecular Formula	C2H6ClF3N2
Molecular Weight	150.53 g/mol
Synonyms	2,2,2-Trifluoroethylhydrazine Hydrochloride; 1-(2,2,2-Trifluoroethyl)hydrazine Hydrochloride; 2,2,2-Trifluoroethanamine, N-amino-, hydrochloride (1:1); Trifluoroethyl Hydrazine HCl; TFH-HCl; (2,2,2-Trifluoroethyl)hydrazine Monohydrochloride
EINECS	Contact for details

Quality Control

Every batch of (2,2,2-Trifluoroethyl)Hydrazinehydrochloride is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and commercial synthesis. Comprehensive analytical testing, including HPLC, NMR, and elemental analysis, is performed to guarantee identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.