Description

1-(2-Methylbutyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound serves as a key intermediate in the synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced materials. Its specific structure offers unique reactivity for constructing pyrazole-containing frameworks.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially those containing the pyrazole heterocycle.
• Suzuki-Miyaura Cross-Coupling Reactions: Used as a boronic ester coupling partner to form carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures.
• Agrochemical Research: Employed in the development of new pesticides and herbicides where the pyrazole moiety is a key pharmacophore.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Used in the design and synthesis of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Item	Detail
Product Name	1-(2-Methylbutyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1080642-19-8
Molecular Formula	C14H25BN2O2
Molecular Weight	264.18 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-methylbutyl)-1H-pyrazole; 1-(2-Methylbutyl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(2-Methylbutyl)pyrazole-4-boronic acid pinacol ester; 1H-Pyrazole-4-boronic acid, 1-(2-methylbutyl)-, pinacol ester; Pyrazole boronic ester derivative; 1080642-19-8; (1-(2-Methylbutyl)-1H-pyrazol-4-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(2-Methylbutyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.