Description

3-[4-(Trifluoromethyl)Phenyl]Cyclobutan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane ring substituted with a trifluoromethylphenyl group. This compound is valued for its unique structural motif, which is crucial for modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel therapeutic candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, particularly in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, contributing to unique material properties.
• Organic Synthesis Scaffold: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its rigid cyclobutane core.
• Fluorine Chemistry: Acts as a valuable substrate for further functionalization, exploring the effects of fluorine substitution in molecular design.

Basic Information

Product Name	3-[4-(Trifluoromethyl)Phenyl]Cyclobutan-1-One
CAS No.	1080636-43-6
Molecular Formula	C11H9F3O
Molecular Weight	214.18 g/mol
Synonyms	3-[4-(Trifluoromethyl)phenyl]cyclobutanone; 1-[4-(Trifluoromethyl)phenyl]cyclobutan-3-one; 4-(Trifluoromethyl)phenyl cyclobutanone; 3-(4-Trifluoromethylphenyl)cyclobutanone; Cyclobutanone, 3-[4-(trifluoromethyl)phenyl]-; 1080636-43-6; α-(4-Trifluoromethylphenyl)cyclobutanone
EINECS	Contact for details

Quality Control

Our 3-[4-(Trifluoromethyl)Phenyl]Cyclobutan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.