Description

2-Chloro-5-Methoxymethylphenylboronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in its enhanced stability and handling properties compared to the free boronic acid, making it a superior reagent for critical cross-coupling reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this boronic ester, crucial for synthesizing biaryl structures found in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly those requiring the specific 2-chloro-5-methoxymethylphenyl moiety.
• Agrochemical Active Ingredient Development: Employed in creating advanced herbicides, fungicides, and insecticides where the substituted phenyl ring is a core structural component.
• Material Science & OLED Research: Serves as a precursor for synthesizing organic electronic materials, such as ligands for metal complexes or direct components of organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for studying biological systems and target engagement.
• Scale-up Process Chemistry: The pinacol ester's stability makes it suitable for kilogram-scale manufacturing processes in pilot plants and commercial production.

Basic Information

Product Name	2-Chloro-5-Methoxymethylphenylboronic Acid Pinacol Ester
CAS No.	1079402-22-4
Molecular Formula	C14H20BClO3
Molecular Weight	282.57 g/mol
Synonyms	2-Chloro-5-(methoxymethyl)phenylboronic acid pinacol ester; (2-Chloro-5-(methoxymethyl)phenyl)boronic acid pinacol ester; 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl methyl ether; [2-Chloro-5-(methoxymethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[2-chloro-5-(methoxymethyl)phenyl]-, 1,1-dimethylethyl ester (9CI); 2-(2-Chloro-5-methoxymethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methoxymethylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.