Description

4,4-Difluoro-1-Hydroxycyclohexane-1-Carboxylic Acid is a high-value fluorinated building block characterized by its unique cyclohexane ring functionalized with both a carboxylic acid and a hydroxyl group, with fluorine atoms at the 4-position. This structure makes it a versatile intermediate for synthesizing complex molecules where the introduction of fluorine atoms can dramatically alter physical, chemical, and biological properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for introducing fluorinated motifs to improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where fluorination enhances activity and environmental persistence.
• Advanced Material Precursor: Serves as a building block for fluorinated polymers, liquid crystals, and other specialty materials requiring specific dielectric or surface properties.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of the difluorocyclohexyl moiety on biological activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	4,4-Difluoro-1-Hydroxycyclohexane-1-Carboxylic Acid
CAS No.	1075221-15-6
Molecular Formula	C7H10F2O3
Molecular Weight	180.15 g/mol
Synonyms	1-Hydroxy-4,4-difluorocyclohexanecarboxylic acid; 4,4-Difluoro-1-hydroxy-1-cyclohexanecarboxylic acid; 4,4-Difluorocyclohexane-1-carboxylic acid-1-ol; 1-Carboxy-4,4-difluorocyclohexanol; Difluorocyclohexanolcarboxylic acid; 4,4-Difluoro-1-hydroxycyclohexanecarboxylic acid; 4,4-Difluorocyclohexanol-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-Hydroxycyclohexane-1-Carboxylic Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay and impurity profiles. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.