Description

2-(2-Fluoro-4-Trifluoromethoxy-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, active ingredient synthesis, and the development of novel functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethoxy and fluoro substituents impart desirable biological activity and environmental persistence profiles.
• Material Science Research: Serves as a building block for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, leveraging its aromatic boronate structure.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other advanced catalytic processes.
• Chemical Biology & Probe Synthesis: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications due to its biocompatible coupling chemistry.
• Custom & Fine Chemical Manufacturing: A critical reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	2-(2-Fluoro-4-Trifluoromethoxy-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1073477-73-2
Molecular Formula	C13H15BF4O3
Molecular Weight	306.07 g/mol
Synonyms	2-Fluoro-4-(trifluoromethoxy)phenylboronic acid pinacol ester; (2-Fluoro-4-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 2-(2-Fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[2-fluoro-4-(trifluoromethoxy)phenyl]-1,3,2-dioxaborolane; Pinacol (2-Fluoro-4-(trifluoromethoxy)phenyl)boronate; 2-Fluoro-4-trifluoromethoxyphenylboronic acid pinacol ester; F-TFMP-BPin
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-4-Trifluoromethoxy-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.