Description

3-(4-Morpholinomethyl)-Phenylboronic Acid Pinacol Ester Hydrochloride is a high-value organoboron building block and pharmaceutical intermediate. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry and materials science. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient synthesis of complex biaryl structures. The hydrochloride salt form enhances stability and handling characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Medicinal Chemistry Research: Enables rapid parallel synthesis and structure-activity relationship (SAR) studies in drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Ligand and Catalyst Development: Building block for creating novel phosphine-free ligands and organometallic catalysts.
• Materials Science: Intermediate in the production of organic electronic materials, such as OLEDs and conductive polymers.

Basic Information

Product Name	3-(4-Morpholinomethyl)-Phenylboronic Acid Pinacol Ester Hydrochloride
CAS No.	1073371-76-2
Molecular Formula	C18H29BNO3 • HCl
Molecular Weight	357.70 g/mol (Free base: 321.24 g/mol)
Synonyms	[3-(4-Morpholinylmethyl)phenyl]boronic acid pinacol ester hydrochloride; 3-(Morpholin-4-ylmethyl)phenylboronic acid pinacol ester HCl; Pinacol [3-(4-Morpholinomethyl)phenyl]boronate hydrochloride; 3-(N-Morpholinomethyl)benzeneboronic acid pinacol ester hydrochloride; B-[3-(4-Morpholinylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane hydrochloride; CAS 1073371-76-2
EINECS	Contact for details

Quality Control

Our 3-(4-Morpholinomethyl)-Phenylboronic Acid Pinacol Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO 9001 compliance for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.