Description

2-[(2-tert-Butyldimethylsilyl)Thienyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronate ester derivative, used in advanced organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing biaryl and heterobiaryl motifs prevalent in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Materials Science Research: Serves as a precursor for creating organic electronic materials, including polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Enables the late-stage functionalization and diversification of complex molecules in hit-to-lead and lead optimization campaigns.
• Catalyst & Ligand Development: Employed in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	2-[(2-tert-Butyldimethylsilyl)Thienyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1073371-74-0
Molecular Formula	C16H31BO2SSi
Molecular Weight	326.39 g/mol
Synonyms	2-(2-(tert-Butyldimethylsilyl)thiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(tert-butyldimethylsilyl)thiophene; 2-(tert-Butyldimethylsilyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; TBDMS-Thiophene Pinacol Boronate; (2-(tert-Butyldimethylsilyl)thiophen-3-yl)boronic acid pinacol ester; 1073371-74-0; Boronic acid, B-[2-[[(1,1-dimethylethyl)dimethylsilyl]thienyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our production of 2-[(2-tert-Butyldimethylsilyl)Thienyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by NMR (1H, 13C, 11B), HPLC, and GC analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.