Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-α-(2-Thiazolyl)Benzyl Alcohol is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its molecular architecture, featuring both a protected boronic acid group and a thiazole heterocycle, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical sectors for applications in medicinal chemistry, catalyst development, and material science.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the thiazole moiety for biological activity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors due to its boronate ester functionality, which can interact with diols and other biological targets.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel ligands used in transition metal catalysis for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-α-(2-Thiazolyl)Benzyl Alcohol
CAS No.	1073371-73-9
Molecular Formula	C16H20BNO3S
Molecular Weight	317.21 g/mol
Synonyms	2-[Hydroxy(2-thiazolyl)methyl]phenylboronic acid pinacol ester; α-(2-Thiazolyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylmethanol; 4-(Pinacolatoboryl)-α-(2-thiazolyl)benzyl alcohol; (2-Thiazolyl)[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-α-(2-Thiazolyl)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container must be kept tightly sealed and opened only under moisture-free conditions to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.