Description

3-Benzyloxy-4-Methoxycarbonylphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected boronic acid building block, offering enhanced stability and handling characteristics for advanced organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for cross-coupling reactions and the construction of complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential in constructing biaryl systems found in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Research: Employed in the synthesis of advanced herbicides, fungicides, and insecticides that require specific aryl-boronate motifs.
• Material Science & OLED Development: Acts as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in display technologies.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Scale-up Process Chemistry: The pinacol ester protection offers improved stability for handling in kilogram-scale manufacturing processes under GMP conditions.

Basic Information

Product Name	3-Benzyloxy-4-Methoxycarbonylphenylboronic Acid, Pinacol Ester
CAS No.	1073355-16-4
Molecular Formula	C22H27BO5
Molecular Weight	382.26 g/mol
Synonyms	(3-(Benzyloxy)-4-(methoxycarbonyl)phenyl)boronic acid pinacol ester; 2-(3-(Benzyloxy)-4-(methoxycarbonyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3-Benzyloxy-4-(methoxycarbonyl)benzeneboronic acid pinacol ester; Methyl 2-benzyloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; Boronic acid, B-[3-(phenylmethoxy)-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester; CAS 1073355-16-4
EINECS	Contact for details

Quality Control

Every batch of 3-Benzyloxy-4-Methoxycarbonylphenylboronic Acid, Pinacol Ester is produced and analyzed under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality protocols are designed to meet the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.