Description

2-((tert-Butyldimethylsilanyl)Ethynyl)-4,4,5,5-Tetramethyl-(1,3,2)Dioxaborolane is a high-value organoboron building block, specifically a silyl-protected ethynyl boronic ester, prized for its stability and reactivity in advanced synthetic chemistry. This compound is essential for facilitating palladium-catalyzed cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is a critical reagent for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and the creation of functional materials and organic electronics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Sonogashira and Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used to construct complex heterocyclic and alkyne-containing compounds for novel crop protection agents.
• Material Science: Building block for conjugated polymers, organic semiconductors, and metal-organic frameworks (MOFs) requiring precise alkyne incorporation.
• Chemical Biology & Bioconjugation: Enables site-specific labeling of biomolecules (proteins, nucleic acids) through bioorthogonal "click" chemistry reactions.
• Ligand & Catalyst Development: Serves as a synthon for creating sophisticated phosphine or N-heterocyclic carbene (NHC) ligands with tailored electronic properties.
• Academic & Process R&D: A versatile reagent for exploring new synthetic methodologies and scaling up target molecule production.

Basic Information

Item	Details
Product Name	2-((tert-Butyldimethylsilanyl)Ethynyl)-4,4,5,5-Tetramethyl-(1,3,2)Dioxaborolane
CAS No.	1073355-02-8
Molecular Formula	C14H27BO2Si
Molecular Weight	266.27 g/mol
Synonyms	2-((tert-Butyldimethylsilyl)ethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (tert-Butyldimethylsilyl)ethynylboronic acid pinacol ester; TBDMS-Ethynyl-Bpin; 2-[(tert-Butyldimethylsilyl)ethynyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (TBDMS-ethynyl)boronic acid pinacol ester; tert-Butyldimethyl(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethynyl)silane
EINECS	Contact for details

Quality Control

Our production of 2-((tert-Butyldimethylsilanyl)Ethynyl)-4,4,5,5-Tetramethyl-(1,3,2)Dioxaborolane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters. We support cGMP and ISO standards for applications requiring the highest level of documentation and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.