Description

E-2-[3,5-Bis(Trifluoromethyl)Phenyl]Vinylboronic Acid Pinacol Ester is a high-value, organoboron building block characterized by its electron-deficient aromatic system and protected boronic acid functionality. This compound is essential for facilitating challenging cross-coupling reactions, particularly Suzuki-Miyaura couplings, due to its enhanced reactivity and stability profile. It is a critical intermediate for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of complex molecules with trifluoromethyl-substituted aromatic cores.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring trifluoromethylated biaryl motifs for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the introduction of the 3,5-bis(trifluoromethyl)phenyl group can improve biological activity and environmental persistence.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and OFETs, where its structure can contribute to electron-transport properties and thermal stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems, leveraging the unique properties of the fluorine atoms.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences industry.

Basic Information

Product Name	E-2-[3,5-Bis(Trifluoromethyl)Phenyl]Vinylboronic Acid Pinacol Ester
CAS No.	1073354-87-6
Molecular Formula	C₁₈H₁₉BF₆O₂
Molecular Weight	392.15 g/mol
Synonyms	(E)-2-(3,5-Bis(trifluoromethyl)phenyl)ethenylboronic acid pinacol ester; 2-[3,5-Bis(trifluoromethyl)phenyl]vinylboronic acid pinacol ester; trans-2-[3,5-Bis(trifluoromethyl)phenyl]vinylboronic acid pinacol ester; (E)-[2-[3,5-Bis(trifluoromethyl)phenyl]ethenyl]boronic acid pinacol ester; B-[2-[3,5-Bis(trifluoromethyl)phenyl]ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,5-Bis(trifluoromethyl)styrylboronic acid pinacol ester; Pinacol (E)-[2-(3,5-bis(trifluoromethyl)phenyl)vinyl]boronate
EINECS	Contact for details

Quality Control

Our production of E-2-[3,5-Bis(Trifluoromethyl)Phenyl]Vinylboronic Acid Pinacol Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized by modern analytical techniques including NMR (1H, 13C, 19F, 11B), HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.