Description

2-Hydroxypyrimidine-5-Boronic Acid, Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing pyrimidine-based drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Enables the creation of organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of molecular probes and sensors.
• Catalyst & Ligand Development: Acts as a precursor for novel ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses producing bespoke organic compounds for clients.

Basic Information

Item	Detail
Product Name	2-Hydroxypyrimidine-5-Boronic Acid, Pinacol Ester
CAS No.	1073354-84-3
Molecular Formula	C10H15BN2O3
Molecular Weight	222.06 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-ol; 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2(1H)-Pyrimidinone, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Hydroxypyrimidine-5-boronic acid pinacol ester; 5-(Pinacolatoboryl)pyrimidin-2-ol
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxypyrimidine-5-Boronic Acid, Pinacol Ester is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our products undergo rigorous quality testing, including HPLC, NMR, and LC-MS, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.