Description

5-Methyl-6-(Methyl-Pivaloylamino)Pyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a key building block in modern organic synthesis. This compound is specifically engineered for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecules. It is an essential raw material for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality boronic ester reagents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures prevalent in modern medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its pyridine-boronic ester structure contributes to bioactive molecule libraries.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Chemical Biology & Probe Development: Utilized as a building block for creating molecular probes and tools to study biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	5-Methyl-6-(Methyl-Pivaloylamino)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1073354-77-4
Molecular Formula	C18H29BN2O3
Molecular Weight	332.25 g/mol
Synonyms	5-Methyl-6-[(2,2-dimethylpropanoyl)(methyl)amino]pyridine-3-boronic acid pinacol ester; 3-Pyridineboronic acid, 5-methyl-6-[(2,2-dimethyl-1-oxopropyl)methylamino]-, 1,1-dimethylethyl ester; 6-(Methylpivalamido)-5-methylpyridin-3-ylboronic acid pinacol ester; 5-Methyl-6-(N-methylpivalamido)pyridin-3-ylboronic acid pinacol ester; Boronic ester intermediate 1073354-77-4; Suzuki-Miyaura coupling reagent.
EINECS	Contact for details

Quality Control

Every batch of 5-Methyl-6-(Methyl-Pivaloylamino)Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity, meeting the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) with full batch traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent hydrolysis and maintain reagent quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.