Description

2-[4-(n-Boc)Piperazin-1-Yl]Phenylboronic Acid Pinacol Ester is a high-purity, protected boronic ester building block designed for advanced organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily utilized by medicinal chemists and process R&D scientists in the pharmaceutical and agrochemical industries for the efficient synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex molecules in drug discovery and development programs, particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-handleable arylboron reagent for palladium-catalyzed coupling with aryl halides or triflates.
• Medicinal Chemistry & SAR Studies: Enables the rapid parallel synthesis and diversification of compound libraries to explore structure-activity relationships.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific aryl-piperazine motifs.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of advanced organic electronic materials and polymers.
• Peptide Mimetics & PROTACs: Facilitates the incorporation of the piperazine-Boc pharmacophore into complex bioactive molecules and proteolysis-targeting chimeras.

Basic Information

Item	Detail
Product Name	2-[4-(n-Boc)Piperazin-1-Yl]Phenylboronic Acid Pinacol Ester
CAS No.	1073354-59-2
Molecular Formula	C21H33BN2O4
Molecular Weight	388.31 g/mol
Synonyms	1-Boc-4-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenylboronic acid pinacol ester; 2-(4-Boc-piperazin-1-yl)phenylboronic acid pinacol ester; tert-Butyl 4-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 1-Boc-4-(2-Bpin-phenyl)piperazine; BOC-Pip-Ph-Bpin; (2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-[4-(n-Boc)Piperazin-1-Yl]Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 97% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via NMR and IR, and impurity profiles. We support development and commercial projects requiring compliance with ICH guidelines and can provide material suitable for cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.