Description

3,5-Difluoro-2-Methoxyphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used to create novel, fluorinated active ingredients for crop protection agents, leveraging the stability and reactivity of the pinacol ester group.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Building block for creating fluorinated organic frameworks, liquid crystals, and polymers with tailored electronic and physical properties.
• Chemical Biology Probes: Utilized in the development of fluorinated probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-fidelity boronic ester coupling partners.

Basic Information

Product Name	3,5-Difluoro-2-Methoxyphenylboronic Acid, Pinacol Ester
CAS No.	1073354-50-3
Molecular Formula	C13H17BF2O3
Molecular Weight	270.08 g/mol
Synonyms	2-Methoxy-3,5-difluorophenylboronic acid pinacol ester; (3,5-Difluoro-2-methoxyphenyl)boronic acid pinacol ester; Pinacol (3,5-difluoro-2-methoxyphenyl)boronate; 3,5-Difluoro-2-methoxybenzeneboronic acid pinacol ester; B-(3,5-Difluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(3,5-difluoro-2-methoxyphenyl)-1,3,2-dioxaborolane; 1073354-50-3; Boronic acid, B-(3,5-difluoro-2-methoxyphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Methoxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.