Description

2-(2,2,2-Trifluoroethoxy)Pyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in enabling the efficient construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality boronic ester reagents for cross-coupling reactions and other synthetic transformations.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those containing pyridine and trifluoroethoxy motifs for improved metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boronic ester partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoroethoxy group can enhance biological activity.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and functional polymers.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of chemical probes and libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized boronic acid derivatives.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1073354-46-7
Molecular Formula	C13H17BF3NO3
Molecular Weight	303.09 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Borono-2-(2,2,2-trifluoroethoxy)pyridine pinacol ester; 2-(Trifluoroethoxy)pyridine-3-boronic acid pinacol ester; [2-(2,2,2-Trifluoroethoxy)pyridin-3-yl]boronic acid pinacol ester; Pyridine-3-boronic acid, 2-(2,2,2-trifluoroethoxy)-, 1,1-dimethylethyl ester; B-[2-(2,2,2-Trifluoroethoxy)-3-pyridinyl]boronic acid pinacol ester; 1073354-46-7; CAS 1073354-46-7
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoroethoxy)Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent quality suitable for demanding applications like pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.