Description

4-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine-boronic ester building block essential for modern synthetic chemistry. This compound matters as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development, where its boronate ester group enables critical Suzuki-Miyaura cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing piperazine and pyridine motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis for high-throughput screening and structure-activity relationship (SAR) studies to identify new therapeutic leads.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides that require specific heterocyclic architectures.
• Chemical Biology Probes: Facilitates the creation of tagged molecules and probes for studying biological pathways and target engagement.
• Advanced Materials Research: A potential monomer or precursor in the development of organic electronic materials and functional polymers.

Basic Information

Product Name	4-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1073354-42-3
Molecular Formula	C20H32BN3O4
Molecular Weight	389.30 g/mol
Synonyms	1-Boc-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine; tert-Butyl 4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate; 2-(1-Boc-piperazin-4-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine-Boronate Ester; 1073354-42-3
EINECS	Contact for details

Quality Control

Our 4-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.