Description

4-Benzyloxy-2-Chloropyrimidine-5-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, specifically designed for advanced cross-coupling reactions. This compound is a critical pharmaceutical intermediate and building block, enabling the efficient construction of complex heterocyclic scaffolds essential for modern drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to construct complex biaryl and heteroaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific pyrimidine-based architectures.
• Material Science & OLED Development: Employed in the synthesis of organic electronic materials, including charge-transport layers and emissive materials for display technologies.
• Chemical Biology & Probe Development: Facilitates the creation of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	4-Benzyloxy-2-Chloropyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1073354-22-9
Molecular Formula	C₁₇H₂₀BClN₂O₃
Molecular Weight	346.62 g/mol
Synonyms	2-Chloro-4-(phenylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-Boronic Acid, 4-(benzyloxy)-2-chloropyrimidine-, Pinacol Ester; 4-(Benzyloxy)-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Chloro-4-benzyloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 4-Benzyloxy-2-chloro-5-pyrimidineboronic acid pinacol ester; B-4-(Benzyloxy)-2-chloro-5-pyrimidinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2-Chloropyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.