Description

2-(5-Chloro-2-Methyl-4-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex drug candidates, especially those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated phenyl structures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(5-Chloro-2-Methyl-4-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1073353-97-5
Molecular Formula	C14H16BClF3O2
Molecular Weight	318.53 g/mol
Synonyms	5-Chloro-2-methyl-4-(trifluoromethyl)phenylboronic acid pinacol ester; (5-Chloro-2-methyl-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-Methyl-5-chloro-4-(trifluoromethyl)phenylboronic acid pinacol ester; Pinacol [5-chloro-2-methyl-4-(trifluoromethyl)phenyl]boronate; CAS 1073353-97-5; Boronic acid, B-[5-chloro-2-methyl-4-(trifluoromethyl)phenyl]-, 1,1,1,1-tetramethyl-1,3,2-benzodioxaborole
EINECS	Contact for details

Quality Control

Our 2-(5-Chloro-2-Methyl-4-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), identity confirmation, and impurity profiles. We support compliance with relevant guidelines for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.