Description

2-(4-Methoxy-2-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1073353-81-7 is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly complex molecules containing biaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable boronic ester reagent for constructing biaryl and heterobiaryl scaffolds, a fundamental transformation in drug discovery.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Utilized for creating molecular probes and labeled compounds for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences market.

Basic Information

Product Name	2-(4-Methoxy-2-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1073353-81-7
Molecular Formula	C₁₃H₁₈BNO₅
Molecular Weight	279.10 g/mol
Synonyms	4-Methoxy-2-nitrophenylboronic acid pinacol ester; (4-Methoxy-2-nitrophenyl)boronic acid pinacol ester; 2-Nitro-4-methoxyphenylboronic acid pinacol ester; Pinacol (4-Methoxy-2-nitrophenyl)boronate; 2-(4-Methoxy-2-nitrophenyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; 4-Methoxy-2-nitrobenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Methoxy-2-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and batch-to-batch consistency suitable for research and process development. Certificates of Analysis (COA) with full analytical data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.