Description

3-Chloro-2-Fluoropyridine-4-Boronic Acid, Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily needed by pharmaceutical, agrochemical, and advanced materials researchers for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing fluorinated and chlorinated pyridine motifs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that require specific halogenated heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers, where the boronic ester group facilitates modular assembly.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems, leveraging its reactivity for bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up processes for clients.

Basic Information

Product Name	3-Chloro-2-Fluoropyridine-4-Boronic Acid, Pinacol Ester
CAS No.	1073353-71-5
Molecular Formula	C11H14BClFNO2
Molecular Weight	257.50 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(3-chloro-2-fluoropyridin-4-yl)-1,3,2-dioxaborolane; 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(3-Chloro-2-fluoropyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-2-fluoro-4-pyridineboronic acid pinacol ester; 3-Chloro-2-fluoropyridine-4-boronic acid pinacol ester; 3-Chloro-2-fluoro-4-(pinacolatoboryl)pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoropyridine-4-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.