Description

2,4-Bis(Trifluoromethyl)Benzeneboronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative. This compound is critical for enabling complex cross-coupling reactions, such as the Suzuki-Miyaura reaction, in advanced chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing molecules with unique electronic and steric properties imparted by the trifluoromethyl groups.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the incorporation of fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl groups contribute to biological activity and environmental persistence profiles.
• Materials Science & OLED Development: Serves as a precursor for synthesizing fluorinated organic semiconductors, liquid crystals, and light-emitting materials for electronic displays.
• Cross-Coupling Reactions: The pinacol ester protecting group enhances stability, making it a preferred reagent over the free boronic acid for demanding Suzuki-Miyaura couplings under various conditions.
• Chemical Research & Development: An essential tool for medicinal chemistry and process chemistry for exploring new chemical space and optimizing synthetic routes.
• Ligand & Catalyst Preparation: Used in the synthesis of specialized ligands and catalysts for asymmetric synthesis and other transition metal-catalyzed processes.

Basic Information

Product Name	2,4-Bis(Trifluoromethyl)Benzeneboronic Acid Pinacol Ester
CAS No.	1073353-65-7
Molecular Formula	C15H17BF6O2
Molecular Weight	354.10 g/mol
Synonyms	2,4-Bis(trifluoromethyl)phenylboronic acid pinacol ester; (2,4-Bis(trifluoromethyl)phenyl)boronic acid pinacol ester; 2,4-Bis(trifluoromethyl)benzeneboronic acid, pinacol ester; 2,4-Bis(trifluoromethyl)phenylboronic acid neopentyl glycol ester (common alternative); 2,4-Di(trifluoromethyl)benzeneboronic acid pinacol ester; 2,4-Di(trifluoromethyl)phenylboronic acid pinacol ester; Pinacol [2,4-bis(trifluoromethyl)phenyl]boronate; B-[2,4-Bis(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,4-Bis(Trifluoromethyl)Benzeneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.