Description

3-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid, Pinacol Ester is a sophisticated boronic ester derivative, a key building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a pyrrolidine-carbonyl moiety that can serve as a versatile handle for further derivatization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel small molecule therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-handleable boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and library synthesis to explore structure-activity relationships (SAR) due to its modular design.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Material Science: A building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, via cross-coupling polymerization.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	3-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid, Pinacol Ester
CAS No.	1073353-61-3
Molecular Formula	C₁₇H₂₄BNO₃
Molecular Weight	301.19 g/mol
Synonyms	[3-(1-Pyrrolidinecarbonyl)phenyl]boronic acid pinacol ester; 3-(N-Pyrrolidylcarbonyl)phenylboronic acid pinacol ester; 3-(Pyrrolidine-1-carbonyl)benzeneboronic acid pinacol ester; Pinacol 3-(pyrrolidine-1-carbonyl)phenylboronate; 1-Pyrrolidinecarboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ester; 3-(Pyrrolidin-1-ylcarbonyl)phenylboronic acid pinacol ester; B-[3-(1-Pyrrolidinecarbonyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive cross-coupling reactions. Certificates of Analysis (COA) with full characterization data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening containers to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.