Description

4-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid, Pinacol Ester is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is crucial for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the discovery and production of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biaryl motifs for kinase inhibitors, antiviral agents, and CNS drugs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, essential for creating complex molecular architectures in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science & OLED Development: Serves as a precursor for constructing organic semiconductors, light-emitting materials, and advanced polymers.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & Contract Research: A vital reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	4-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid, Pinacol Ester
CAS No.	1073353-55-5
Molecular Formula	C17H24BNO3
Molecular Weight	301.19 g/mol
Synonyms	4-(1-Pyrrolidinecarbonyl)benzeneboronic acid pinacol ester; 4-(Pyrrolidine-1-carbonyl)phenylboronic acid pinacol ester; [4-(Pyrrolidine-1-carbonyl)phenyl]boronic acid pinacol ester; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]pyrrolidine; 4-(N-Pyrrolidylcarbonyl)phenylboronic acid pinacol ester; B-[4-(1-Pyrrolidinylcarbonyl)phenyl]boronic acid pinacol ester; Pinacol 4-(pyrrolidine-1-carbonyl)phenylboronate
EINECS	Contact for details

Quality Control

Our 4-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.