Description

5-Bromo-2-Fluoro-3-(4,4,5,5-Tetramethyl-[1,3,2]-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a halogenated pyridine core with a protected boronic ester, enabling efficient cross-coupling reactions like Suzuki-Miyaura. This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to create novel pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Building Block: Employed in the development of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Cross-Coupling Reactions: The pinacol boronate ester group serves as a versatile handle for Suzuki-Miyaura coupling with various aryl/heteroaryl halides.
• Medicinal Chemistry Research: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies in drug discovery programs.
• Chemical Biology Probes: Used to create labeled compounds or probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-(4,4,5,5-Tetramethyl-[1,3,2]-Dioxaborolan-2-Yl)Pyridine
CAS No.	1073353-50-0
Molecular Formula	C11H14BBrFNO2
Molecular Weight	300.95 g/mol
Synonyms	2-Fluoro-5-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Boronic acid, 5-bromo-2-fluoropyridine-3-, pinacol ester; 5-Bromo-2-fluoro-3-pyridineboronic acid pinacol ester; 5-Bromo-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (5-Bromo-2-fluoropyridin-3-yl)boronic acid pinacol ester; 1073353-50-0; 5-Br-2-F-3-PyBpin
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-3-(4,4,5,5-Tetramethyl-[1,3,2]-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature: 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.