Description

2-[2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1073339-21-5 is a high-purity organoboron reagent, specifically a pinacol boronic ester, featuring a trifluoromethylphenyl substituent. This compound is a critical building block in modern synthetic chemistry, enabling the efficient construction of complex molecules through cross-coupling reactions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that incorporate the trifluoromethyl group for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed as a bioconjugation reagent or probe for labeling and studying biological systems.
• Ligand & Catalyst Development: Utilized in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a specific aryl-boronate moiety.

Basic Information

Product Name	2-[2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1073339-21-5
Molecular Formula	C₁₃H₁₆BF₃O₂
Molecular Weight	272.07 g/mol
Synonyms	2-(2-(Trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [2-(Trifluoromethyl)phenyl]boronic acid pinacol ester; 2-(Trifluoromethyl)phenylboronic acid pinacol ester; 2-(2-Trifluoromethylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; 1,3,2-Dioxaborolane, 2-[2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-; (2-(Trifluoromethyl)phenyl)boronic acid, pinacol ester; 2-(α,α,α-Trifluoro-o-tolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 2-[2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for advanced applications and can tailor quality specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.