Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-(2,3,4,5-Tetrafluorophenyl)- is a high-purity, organoboron building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules via cross-coupling reactions, enabling the introduction of a fluorinated aryl moiety. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional polymers.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical reagent for forming carbon-carbon bonds between fluorinated aryl groups and various organohalides or triflates.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy.
• Materials Science Research: Employed in the development of organic light-emitting diodes (OLEDs), liquid crystals, and other fluorinated functional polymers.
• Medicinal Chemistry & Drug Discovery: Facilitates rapid parallel synthesis and library generation for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-(2,3,4,5-Tetrafluorophenyl)-
CAS No.	1073339-20-4
Molecular Formula	C12H13BF4O2
Molecular Weight	276.04 g/mol
Synonyms	2-(2,3,4,5-Tetrafluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2,3,4,5-tetrafluorophenyl)-1,3,2-dioxaborolane; (2,3,4,5-Tetrafluorophenyl)boronic acid pinacol ester; 2,3,4,5-Tetrafluorophenylboronic acid pinacol ester; TetrafluorophenylBPin; Pinacol (2,3,4,5-tetrafluorophenyl)boronate
EINECS	Contact for details

Quality Control

Our production of this high-value boronic ester adheres to strict quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.