Description

trans-4-(Trifluoromethyl)Cyclohexanamine is a versatile chiral amine building block featuring a trifluoromethyl group in the trans configuration on a cyclohexane ring. This compound is valued for its ability to impart unique physicochemical properties, such as enhanced metabolic stability and lipophilicity, to target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Fluorine Chemistry Building Block: A valuable source of a rigid, aliphatic trifluoromethyl group for structure-activity relationship (SAR) studies in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	trans-4-(Trifluoromethyl)Cyclohexanamine
CAS No.	1073266-02-0
Molecular Formula	C7H12F3N
Molecular Weight	167.17 g/mol
Synonyms	trans-4-(Trifluoromethyl)cyclohexanamine; (1r,4r)-4-(Trifluoromethyl)cyclohexan-1-amine; 4-(Trifluoromethyl)cyclohexanamine (trans); trans-4-Aminomethyl-alpha,alpha,α-trifluorotoluene; 4-(Trifluoromethyl)-1-cyclohexanamine (trans); 4-(Trifluoromethyl)cyclohexylamine (trans); (trans)-4-(Trifluoromethyl)cyclohexan-1-amine
EINECS	Contact for details

Quality Control

Our trans-4-(Trifluoromethyl)Cyclohexanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.