Description

Tetrahydropyran-4-Boronic Acid is a versatile organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This high-purity intermediate is critically needed by pharmaceutical, agrochemical, and advanced materials research and development teams for the synthesis of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the tetrahydropyran scaffold.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers through precise molecular engineering.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid partner for palladium-catalyzed coupling with aryl/vinyl halides, enabling library synthesis for drug discovery.
• Chemical Biology & Proteomics: Utilized as a handle for bioconjugation and the development of chemical probes and inhibitors.
• Catalyst & Ligand Development: Acts as a precursor for creating novel boron-containing catalysts and chiral ligands for asymmetric synthesis.

Basic Information

Product Name	Tetrahydropyran-4-Boronic Acid
CAS No.	1072952-46-5
Molecular Formula	C5H11BO3
Molecular Weight	129.95 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)tetrahydropyran; THP-4-Boronic Acid; Tetrahydropyran-4-ylboronic Acid; 4-Boronotetrahydropyran; 2-(Oxan-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Tetrahydropyranboronic Acid; 4-Pyranylboronic Acid (tetrahydro-); 4-THP-Boronic Acid
EINECS	Contact for details

Quality Control

Our Tetrahydropyran-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially moisture-sensitive nature. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.