Description

3-Picoline-4-Boronic Acid Hcl is a high-purity boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its value lies in its crucial role as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop active pharmaceutical ingredients (APIs), novel crop protection agents, and functional organic molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those containing pyridine and biphenyl motifs via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Serves as a building block for creating organic ligands, metal-organic frameworks (MOFs), and polymers with tailored electronic or photophysical properties.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and inhibitors that target specific enzymes or biological pathways.
• Catalyst & Ligand Development: Utilized for synthesizing novel palladium ligands and other catalytic systems used in fine chemical manufacturing.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3-Picoline-4-Boronic Acid Hcl
CAS No.	1072952-40-9
Molecular Formula	C6H9BClNO2
Molecular Weight	173.41 g/mol
Synonyms	(4-Methylpyridin-3-yl)boronic acid hydrochloride; 3-(4-Methylpyridyl)boronic acid hydrochloride; 3-Pyridylboronic acid, 4-methyl-, hydrochloride; 4-Methyl-3-pyridineboronic acid HCl salt; 3-Picoline-4-boronic acid hydrochloride; 3-(4-Methyl-3-pyridinyl)boronic acid hydrochloride; Boronic acid, B-(4-methyl-3-pyridinyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-Picoline-4-Boronic Acid Hcl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are supported by comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, impurity profile, and residual solvents. We are committed to meeting the stringent requirements of research and cGMP manufacturing environments, with specifications available to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.