Description

2-Chloro-4-Methoxypyridine-3-Boronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling the efficient construction of complex molecules through reliable cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine chemicals. Its specific substitution pattern makes it a sought-after intermediate for creating novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group makes this compound an ideal partner for palladium-catalyzed cross-coupling, a fundamental reaction for forming carbon-carbon bonds in complex molecule assembly.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging the pyridine core for biological activity.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	2-Chloro-4-Methoxypyridine-3-Boronic Acid
CAS No.	1072946-19-0
Molecular Formula	C6H7BClNO3
Molecular Weight	187.39 g/mol
Synonyms	(2-Chloro-4-methoxypyridin-3-yl)boronic acid; 2-Chloro-4-methoxy-3-pyridineboronic acid; 3-Borono-2-chloro-4-methoxypyridine; 2-Chloro-4-methoxypyridine-3-boronic acid pinacol ester (common derivative); 1072946-19-0; 2-Chloro-4-methoxy-3-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Methoxypyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.