Description

2-(4-(Chloromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a chloromethyl-substituted phenylboronic ester. This compound is critical for enabling advanced cross-coupling reactions, particularly the Suzuki-Miyaura coupling, due to its dual functionality. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials. The product, identified by CAS number 1072945-04-0, offers a stable and reactive handle for constructing biaryl and conjugated systems.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), especially those containing biphenyl or extended aromatic scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient carbon-carbon bond formation.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and functional materials with tailored electronic properties.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is required.
• Agrochemical Synthesis: Acts as a building block for developing advanced crop protection agents with complex aromatic backbones.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.

Basic Information

Product Name	2-(4-(Chloromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1072945-04-0
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	4-(Chloromethyl)phenylboronic acid pinacol ester; (4-(Chloromethyl)phenyl)boronic acid pinacol ester; 1-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylbenzene; 2-[4-(Chloromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(Pinacolatoboryl)benzyl chloride; p-(Chloromethyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 2-(4-(Chloromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.