Description

2-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetic Acid is a high-value boronic ester derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its primary commercial value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex biaryl and heterobiaryl structures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing biphenyl or substituted phenylacetic acid motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/vinyl boronic esters and aryl/vinyl halides under palladium catalysis, a cornerstone of modern medicinal chemistry.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aryl-acetic acid structures.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate ligands or functionalized materials for catalytic systems.
• Organic Electronic Materials: Potential monomer for constructing conjugated polymers or small molecules used in OLEDs, OFETs, and other optoelectronic devices.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or activity-based probes for studying biological pathways and protein functions.

Basic Information

Product Name	2-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetic Acid
CAS No.	1072945-02-8
Molecular Formula	C16H23BO4
Molecular Weight	290.16 g/mol
Synonyms	[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid; 2-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid; 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanoic acid; o-(Pinacolboryl)phenylacetic Acid; (2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid; 2-(2-(Pinacolboron)phenyl)acetic Acid; B-(2-Carboxymethylphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity, purity, and the absence of critical impurities like palladium residues. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Palladium	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.