Description

2,6-Difluoropyridine-3-Boronic Acid, Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing fluorinated pyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic scaffolds.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, enzyme inhibitors, and compound libraries for drug discovery programs.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated, fluorinated ligands for transition metal catalysis, enhancing catalyst performance and selectivity.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2,6-Difluoropyridine-3-Boronic Acid, Pinacol Ester
CAS No.	1072945-00-6
Molecular Formula	C11H14BF2NO2
Molecular Weight	241.05 g/mol
Synonyms	2,6-Difluoro-3-pyridineboronic acid pinacol ester; (2,6-Difluoropyridin-3-yl)boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluoropyridine; 2,6-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2,6-Difluoropyridine-3-boronic acid neopentyl glycol ester (common alternative); 2,6-Difluoro-3-pyridinylboronic acid pinacol ester; Boronic acid, B-(2,6-difluoro-3-pyridinyl)-, 1,1-dimethylethyl ester (related); 1072945-00-6
EINECS	Contact for details

Quality Control

Our 2,6-Difluoropyridine-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks for pharmaceutical development, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.